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Journal of Virology, September 2000, p. 8183-8187, Vol. 74, No. 17
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Mouse Mammary Tumor Virus Transcription Enhancers for Hematopoietic Progenitor and Mammary Gland Cells Share Functional Elements

Frank U. Reuss1,* and John M. Coffin2

Forschungsschwerpunkt Angewandte Tumorvirologie F0400, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany,1 and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 021112

Received 27 January 2000/Accepted 31 May 2000

Expression of mouse mammary tumor virus (MMTV)-encoded superantigens in B lymphocytes is required for viral transmission and pathogenesis. We have previously established a critical role of an enhancer element within the long terminal repeat (LTR) for MMTV sag gene expression in B-lymphoid progenitor cells. We now demonstrate enhancer activity of this element in a promyelocytic progenitor cell line. We also map the position of the enhancer within the U3 region of the MMTV LTR and show that the progenitor cell enhancer shares functional elements with a previously described mammary gland-specific enhancer.

* Corresponding author. Mailing address: Deutsches Krebsforschungszentrum, Forschungsschwerpunkt Angewandte Tumorvirologie F0400, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany. Phone: 49-6221-424657. Fax: 49-6221-424902. E-mail: f.reuss{at}dkfz-heidelberg.de.

Journal of Virology, September 2000, p. 8183-8187, Vol. 74, No. 17
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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