This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murphy, C. G.
Right arrow Articles by Desrosiers, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murphy, C. G.
Right arrow Articles by Desrosiers, R. C.

 Previous Article  |  Next Article 

Journal of Virology, September 2000, p. 7745-7754, Vol. 74, No. 17
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Vaccine Protection against Simian Immunodeficiency Virus by Recombinant Strains of Herpes Simplex Virus

Cynthia G. Murphy,1 William T. Lucas,1 Robert E. Means,2 Susan Czajak,2 Corrina L. Hale,2 Jeffrey D. Lifson,3 Amitinder Kaur,2 R. Paul Johnson,2 David M. Knipe,1,* and Ronald C. Desrosiers2,*

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115-57161; New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-91022; and AIDS Vaccine Program, SAIC Frederick, NCI-Frederick Cancer Research & Development Center, Frederick, Maryland 217023

Received 15 February 2000/Accepted 22 May 2000

An effective vaccine for AIDS may require development of novel vectors capable of eliciting long-lasting immune responses. Here we report the development and use of replication-competent and replication-defective strains of recombinant herpes simplex virus (HSV) that express envelope and Nef antigens of simian immunodeficiency virus (SIV). The HSV recombinants induced antienvelope antibody responses that persisted at relatively stable levels for months after the last administration. Two of seven rhesus monkeys vaccinated with recombinant HSV were solidly protected, and another showed a sustained reduction in viral load following rectal challenge with pathogenic SIVmac239 at 22 weeks following the last vaccine administration. HSV vectors thus show great promise for being able to elicit persistent immune responses and to provide durable protection against AIDS.

* Corresponding author. Mailing address for David M. Knipe: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115-5716. Phone: (617) 432-1934. Fax: (617) 432-0223. E-mail: david_knipe{at}hms.harvard.edu. Mailing address for Ronald C. Desrosiers: New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Dr., Box 9102, Southborough, MA 01772-9102. Phone: (508) 624-8002. Fax: (508) 460-0612. E-mail: ronald_desrosiers{at}hms.harvard.edu.

Journal of Virology, September 2000, p. 7745-7754, Vol. 74, No. 17
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Haut, L. H., Ertl, H. C. J. (2009). Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine. J. Leukoc. Biol. 86: 779-793 [Abstract] [Full Text]  
  • Schoenly, K. A., Weiner, D. B. (2008). Human Immunodeficiency Virus Type 1 Vaccine Development: Recent Advances in the Cytotoxic T-Lymphocyte Platform "Spotty Business". J. Virol. 82: 3166-3180 [Full Text]  
  • Rollman, E., Smith, M. Z., Brooks, A. G., Purcell, D. F. J., Zuber, B., Ramshaw, I. A., Kent, S. J. (2007). Killing Kinetics of Simian Immunodeficiency Virus-Specific CD8+ T Cells: Implications for HIV Vaccine Strategies. J. Immunol. 179: 4571-4579 [Abstract] [Full Text]  
  • Brockman, M. A., Verschoor, A., Zhu, J., Carroll, M. C., Knipe, D. M. (2006). Optimal Long-Term Humoral Responses to Replication-Defective Herpes Simplex Virus Require CD21/CD35 Complement Receptor Expression on Stromal Cells. J. Virol. 80: 7111-7117 [Abstract] [Full Text]  
  • Wilson, N. A., Reed, J., Napoe, G. S., Piaskowski, S., Szymanski, A., Furlott, J., Gonzalez, E. J., Yant, L. J., Maness, N. J., May, G. E., Soma, T., Reynolds, M. R., Rakasz, E., Rudersdorf, R., McDermott, A. B., O'Connor, D. H., Friedrich, T. C., Allison, D. B., Patki, A., Picker, L. J., Burton, D. R., Lin, J., Huang, L., Patel, D., Heindecker, G., Fan, J., Citron, M., Horton, M., Wang, F., Liang, X., Shiver, J. W., Casimiro, D. R., Watkins, D. I. (2006). Vaccine-Induced Cellular Immune Responses Reduce Plasma Viral Concentrations after Repeated Low-Dose Challenge with Pathogenic Simian Immunodeficiency Virus SIVmac239.. J. Virol. 80: 5875-5885 [Abstract] [Full Text]  
  • Lauterbach, H., Ried, C., Epstein, A. L., Marconi, P., Brocker, T. (2005). Reduced immune responses after vaccination with a recombinant herpes simplex virus type 1 vector in the presence of antiviral immunity. J. Gen. Virol. 86: 2401-2410 [Abstract] [Full Text]  
  • Martin, F., Roth, D. M., Jans, D. A., Pouton, C. W., Partridge, L. J., Monk, P. N., Moseley, G. W. (2005). Tetraspanins in Viral Infections: a Fundamental Role in Viral Biology?. J. Virol. 79: 10839-10851 [Full Text]  
  • Redwood, A. J., Messerle, M., Harvey, N. L., Hardy, C. M., Koszinowski, U. H., Lawson, M. A., Shellam, G. R. (2005). Use of a Murine Cytomegalovirus K181-Derived Bacterial Artificial Chromosome as a Vaccine Vector for Immunocontraception. J. Virol. 79: 2998-3008 [Abstract] [Full Text]  
  • Augustinova, H., Hoeller, D., Yao, F. (2004). The Dominant-Negative Herpes Simplex Virus Type 1 (HSV-1) Recombinant CJ83193 Can Serve as an Effective Vaccine against Wild-Type HSV-1 Infection in Mice. J. Virol. 78: 5756-5765 [Abstract] [Full Text]  
  • Lauterbach, H., Kerksiek, K. M., Busch, D. H., Berto, E., Bozac, A., Mavromara, P., Manservigi, R., Epstein, A. L., Marconi, P., Brocker, T. (2004). Protection from Bacterial Infection by a Single Vaccination with Replication-Deficient Mutant Herpes Simplex Virus Type 1. J. Virol. 78: 4020-4028 [Abstract] [Full Text]  
  • Giri, M., Ugen, K. E., Weiner, D. B. (2004). DNA Vaccines against Human Immunodeficiency Virus Type 1 in the Past Decade. Clin. Microbiol. Rev. 17: 370-389 [Abstract] [Full Text]  
  • Patterson, L. J., Malkevitch, N., Venzon, D., Pinczewski, J., Gomez-Roman, V. R., Wang, L., Kalyanaraman, V. S., Markham, P. D., Robey, F. A., Robert-Guroff, M. (2004). Protection against Mucosal Simian Immunodeficiency Virus SIVmac251 Challenge by Using Replicating Adenovirus-SIV Multigene Vaccine Priming and Subunit Boosting. J. Virol. 78: 2212-2221 [Abstract] [Full Text]  
  • Blancou, P., Chenciner, N., Fang, R. H. T., Monceaux, V., Cumont, M.-C., Guetard, D., Hurtrel, B., Wain-Hobson, S. (2004). Simian Immunodeficiency Virus Promoter Exchange Results in a Highly Attenuated Strain That Protects against Uncloned Challenge Virus. J. Virol. 78: 1080-1092 [Abstract] [Full Text]  
  • Vogel, T. U., Reynolds, M. R., Fuller, D. H., Vielhuber, K., Shipley, T., Fuller, J. T., Kunstman, K. J., Sutter, G., Marthas, M. L., Erfle, V., Wolinsky, S. M., Wang, C., Allison, D. B., Rud, E. W., Wilson, N., Montefiori, D., Altman, J. D., Watkins, D. I. (2003). Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239. J. Virol. 77: 13348-13360 [Abstract] [Full Text]  
  • Evans, D. T., Chen, L.-M., Gillis, J., Lin, K.-C., Harty, B., Mazzara, G. P., Donis, R. O., Mansfield, K. G., Lifson, J. D., Desrosiers, R. C., Galan, J. E., Johnson, R. P. (2003). Mucosal Priming of Simian Immunodeficiency Virus-Specific Cytotoxic T-Lymphocyte Responses in Rhesus Macaques by the Salmonella Type III Secretion Antigen Delivery System. J. Virol. 77: 2400-2409 [Abstract] [Full Text]  
  • Voss, G., Manson, K., Montefiori, D., Watkins, D. I., Heeney, J., Wyand, M., Cohen, J., Bruck, C. (2002). Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine. J. Virol. 77: 1049-1058 [Abstract] [Full Text]  
  • Vogel, T. U., Horton, H., Fuller, D. H., Carter, D. K., Vielhuber, K., O'Connor, D. H., Shipley, T., Fuller, J., Sutter, G., Erfle, V., Wilson, N., Picker, L. J., Watkins, D. I. (2002). Differences Between T Cell Epitopes Recognized After Immunization and After Infection. J. Immunol. 169: 4511-4521 [Abstract] [Full Text]  
  • Vogel, T. U., Friedrich, T. C., O'Connor, D. H., Rehrauer, W., Dodds, E. J., Hickman, H., Hildebrand, W., Sidney, J., Sette, A., Hughes, A., Horton, H., Vielhuber, K., Rudersdorf, R., de Souza, I. P., Reynolds, M. R., Allen, T. M., Wilson, N., Watkins, D. I. (2002). Escape in One of Two Cytotoxic T-Lymphocyte Epitopes Bound by a High-Frequency Major Histocompatibility Complex Class I Molecule, Mamu-A*02: a Paradigm for Virus Evolution and Persistence?. J. Virol. 76: 11623-11636 [Abstract] [Full Text]  
  • Horton, H., Vogel, T. U., Carter, D. K., Vielhuber, K., Fuller, D. H., Shipley, T., Fuller, J. T., Kunstman, K. J., Sutter, G., Montefiori, D. C., Erfle, V., Desrosiers, R. C., Wilson, N., Picker, L. J., Wolinsky, S. M., Wang, C., Allison, D. B., Watkins, D. I. (2002). Immunization of Rhesus Macaques with a DNA Prime/Modified Vaccinia Virus Ankara Boost Regimen Induces Broad Simian Immunodeficiency Virus (SIV)-Specific T-Cell Responses and Reduces Initial Viral Replication but Does Not Prevent Disease Progression following Challenge with Pathogenic SIVmac239. J. Virol. 76: 7187-7202 [Abstract] [Full Text]  
  • Hocknell, P. K., Wiley, R. D., Wang, X., Evans, T. G., Bowers, W. J., Hanke, T., Federoff, H. J., Dewhurst, S. (2002). Expression of Human Immunodeficiency Virus Type 1 gp120 from Herpes Simplex Virus Type 1-Derived Amplicons Results in Potent, Specific, and Durable Cellular and Humoral Immune Responses. J. Virol. 76: 5565-5580 [Abstract] [Full Text]  
  • Brockman, M. A., Knipe, D. M. (2002). Herpes Simplex Virus Vectors Elicit Durable Immune Responses in the Presence of Preexisting Host Immunity. J. Virol. 76: 3678-3687 [Abstract] [Full Text]  
  • Crotty, S., Miller, C. J., Lohman, B. L., Neagu, M. R., Compton, L., Lu, D., Lu, F. X.-S., Fritts, L., Lifson, J. D., Andino, R. (2001). Protection against Simian Immunodeficiency Virus Vaginal Challenge by Using Sabin Poliovirus Vectors. J. Virol. 75: 7435-7452 [Abstract] [Full Text]  
  • Kaur, A., Hale, C. L., Ramanujan, S., Jain, R. K., Johnson, R. P. (2000). Differential Dynamics of CD4+ and CD8+ T-Lymphocyte Proliferation and Activation in Acute Simian Immunodeficiency Virus Infection. J. Virol. 74: 8413-8424 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»