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Journal of Virology, August 2000, p. 7694-7697, Vol. 74, No. 16
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of a Novel Respiratory Syncytial Virus-Specific Human Cytotoxic T-Lymphocyte Epitope

Philip J. R. Goulder,1,2,* Franziska Lechner,3 Paul Klenerman,3 Kenneth McIntosh,2 and Bruce D. Walker1

Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 021291; Division of Infectious Diseases, The Children's Hospital, Boston, Massachusetts 021152; and Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom3

Received 3 April 2000/Accepted 17 May 2000

Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8+ T cells.

* Corresponding author. Mailing address: Partners AIDS Research Center, Massachusetts General Hospital, 13th St., Bldg. 149, Rm. 5218, Charlestown, MA 02129. Phone: (617) 726-5787. Fax: (617) 726-5411. E-mail: goulder{at}helix.mgh.harvard.edu.

Journal of Virology, August 2000, p. 7694-7697, Vol. 74, No. 16
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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