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Journal of Virology, August 2000, p. 7694-7697, Vol. 74, No. 16
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Characterization of a Novel Respiratory Syncytial
Virus-Specific Human Cytotoxic T-Lymphocyte Epitope
Philip J. R.
Goulder,1,2,*
Franziska
Lechner,3
Paul
Klenerman,3
Kenneth
McIntosh,2 and
Bruce D.
Walker1
Partners AIDS Research Center, Massachusetts
General Hospital, Charlestown, Massachusetts
021291; Division of Infectious Diseases,
The Children's Hospital, Boston, Massachusetts
021152; and Nuffield Department of
Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United
Kingdom3
Received 3 April 2000/Accepted 17 May 2000
Respiratory syncytial virus (RSV) infection is a major cause of
morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA
B7-restricted epitope in nucleoprotein (NP) was detectable in four
healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8+ T cells.
*
Corresponding author. Mailing address: Partners AIDS
Research Center, Massachusetts General Hospital, 13th St., Bldg. 149, Rm. 5218, Charlestown, MA 02129. Phone: (617) 726-5787. Fax: (617) 726-5411. E-mail: goulder{at}helix.mgh.harvard.edu.
Journal of Virology, August 2000, p. 7694-7697, Vol. 74, No. 16
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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