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Journal of Virology, August 2000, p. 7691-7693, Vol. 74, No. 16
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Initial Interactions of Subgenus D Adenoviruses with A549 Cellular Receptors: Sialic Acid versus alpha v Integrins

Niklas Arnberg,* Alistair H. Kidd, Karin Edlund, Farzad Olfat, and Göran Wadell

Department of Virology, University of Umeå, S-90185 Umeå, Sweden

Received 10 January 2000/Accepted 16 May 2000

Selected members of the adenovirus family have been shown to interact with the coxsackie adenovirus receptor, alpha v integrins, and sialic acid on target cells. Initial interactions of subgenus D adenoviruses with target cells have until now been poorly characterized. Here, we demonstrate that adenovirus type 8 (Ad8), Ad19a, and Ad37 use sialic acid as a functional cellular receptor, whereas the Ad9 and Ad19 prototypes do not.

* Corresponding author. Mailing address: Department of Virology, University of Umeå, S-90185 Umeå, Sweden. Phone: 46 90 7852891. Fax: 46 90 129905. E-mail: niklas.arnberg{at}climi.umu.se.

Journal of Virology, August 2000, p. 7691-7693, Vol. 74, No. 16
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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