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Journal of Virology, August 2000, p. 7146-7150, Vol. 74, No. 15
Departments of Microbiology and
Immunology1 and
Pathology,2 Dalhousie University,
Halifax, Nova Scotia B3H 4H7, Canada
Received 29 February 2000/Accepted 3 May 2000
We report here the first demonstration of dengue virus infection
and vasoactive cytokine response of a cell of the mast cell/basophil lineage. Infection of KU812 cells was dependent on dengue-specific antibody and gave rise to infectious virions. This antibody-enhanced dengue virus infection triggered a four- to fivefold increase in the
release of interleukin-1
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Release of Vasoactive Cytokines by
Antibody-Enhanced Dengue Virus Infection of a Human Mast
Cell/Basophil Line
(IL-1
) and a modest increase for IL-6
but not for an alternate cytokine, granulocyte-macrophage colony-stimulating factor. The results suggest a potential role for
mast cells/basophils in the pathogenesis of dengue virus-induced disease.
*
Corresponding author. Mailing address: Department of
Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada. Phone: (902) 494-1063. Fax: (902) 494-5125. E-mail: Robert.Anderson{at}dal.ca.
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