Mature Dendritic Cells Infected with Herpes Simplex Virus Type 1 Exhibit Inhibited T-Cell Stimulatory Capacity

doi:10.1128/JVI.74.15.7127-7136.2000

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Journal of Virology, August 2000, p. 7127-7136, Vol. 74, No. 15
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Mature Dendritic Cells Infected with Herpes Simplex Virus Type 1 Exhibit Inhibited T-Cell Stimulatory Capacity

Monika Kruse,¹^,^* Olaf Rosorius,² Friedrich Krätzer,² Gerhard Stelz,² Christine Kuhnt,¹ Gerold Schuler,¹ Joachim Hauber,² and Alexander Steinkasserer¹

Department of Dermatology¹ and Institute for Clinical and Molecular Virology,² University of Erlangen-Nürnberg, Erlangen, Germany

Received 29 November 1999/Accepted 26 April 2000

Mature dendritic cells (DC) are the most potent antigen-presenting cells within the entire immune system. Interference withthe function of these cells therefore constitutes a very powerfulmechanism for viruses to escape immune responses. Several membersof the Herpesviridae family have provided examples of such escapestrategies, including interference with antigen presentation andproduction of homologous cytokines. In this study we investigatedthe infection of mature DC with herpes simplex virus type 1 (HSV-1)and the way in which infection alters the phenotype and functionof mature DC. Interestingly, the T-cell-stimulatory capacity ofthese DC was strongly impaired. Furthermore, we demonstrated thatHSV-1 leads to the specific degradation of CD83, a cell surfacemolecule which is specifically upregulated during DC maturation.These data indicate that HSV-1 has developed yet another novelmechanism to escape immuneresponses.

^* Corresponding author. Mailing address: Department of Dermatology, University of Erlangen-Nürnberg, Hartmannstrasse 14, D-91052Erlangen, Germany. Phone: 49-9131-853-3734. Fax: 49-9131-853-5799.E-mail: kruse{at}derma.med.uni-erlangen.de.

Journal of Virology, August 2000, p. 7127-7136, Vol. 74, No. 15
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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