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Journal of Virology, August 2000, p. 6984-6991, Vol. 74, No. 15
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Early Therapy of Vertical Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Control of Viral Replication and Absence of Persistent HIV-1-Specific Immune Responses

Katherine Luzuriaga,1,2,* Margaret McManus,1,2 Michelle Catalina,1,2 Shane Mayack,3 Mark Sharkey,2 Mario Stevenson,2 and John L. Sullivan1,2,dagger for the Pactg 356 Investigators

Department of Pediatrics1 and Program in Molecular Medicine,2 University of Massachusetts Medical School, Worcester, Massachusetts 01605, and Graduate Program in Immunology/Virology, University of Massachusetts Medical School, Worcester, Massachusetts 016553

Received 9 February 2000/Accepted 1 May 2000

Studies of potent antiretroviral combination regimens were undertaken in young infants to evaluate the potential for long-term suppression of viral replication and to evaluate the immune consequences of such therapies. Early combination antiretroviral therapy led to a loss of plasma viremia, cultivable virus, and labile extrachromosomal replication intermediates. Despite preservation of immune function, persistent human immunodeficiency type 1 (HIV-1)-specific immune responses were not detected in most infants. The absence of detectable, persisting immune responses in most HIV-1-infected infants treated early contrasts with what is typically seen in adults who are treated early. These results are consistent with the notion that early combination antiretroviral therapy of HIV-1-infected infants allows the long-term suppression of viral replication.

* Corresponding author. Mailing address: Pediatrics/Molecular Medicine, Suite 318, Biotech 2, 373 Plantation St., Worcester, MA 01605. Phone: (508) 856-6282. Fax: (508) 856-5500. E-mail: katherine.luzuriaga{at}umassmed.edu.

dagger PACTG 356 investigators who contributed to this study include: Hannah Gay, University of Mississippi Medical School; Peter Vink, University of Maryland; Savita Pahwa and Saroj Bakshi, North Shore University Hospital---New York University School of Medicine; William Borkowsky, New York University School of Medicine; Coleen Cunningham, Syracuse University; Stephen Pelton, Boston Medical Center; Stephen Spector, University of California, San Diego; Lynne Mofenson, National Institute of Child Health and Human Development, National Institutes of Health; and Betsy Smith, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

Journal of Virology, August 2000, p. 6984-6991, Vol. 74, No. 15
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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