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 Previous Article

Journal of Virology, July 2000, p. 6695-6699, Vol. 74, No. 14
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary CD4+ T Lymphocytes, Monocytes, and Dendritic Cells by Cytotoxic T Lymphocytes

Michael E. Severino,1 Nikolaos V. Sipsas,1 Phuong Thi Nguyen,1 Spyros A. Kalams,1 Bruce D. Walker,1 R. Paul Johnson,2 and Otto O. Yang1,*

AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129,1 and Massachusetts General Hospital and New England Regional Primate Center, Southborough, Massachusetts 017722

Received 10 February 2000/Accepted 19 April 2000

We demonstrate that human immunodeficiency virus type 1 (HIV-1)-specific CD8+ cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells individually. Viral inhibition is significantly diminished in lymphocyte-dendritic cell clusters, suggesting that these clusters in vivo could be sites where viral replication is more difficult to control by CTL.

* Corresponding author. Present address: Division of Infectious Diseases, 37-121 CHS, UCLA Medical Center, 10833 LeConte Ave., Los Angeles, CA 90095. Phone: (310) 794-9491. Fax: (310) 825-3632. E-mail: OYang{at}mednet.ucla.edu.

Journal of Virology, July 2000, p. 6695-6699, Vol. 74, No. 14
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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