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Journal of Virology, July 2000, p. 6648-6651, Vol. 74, No. 14
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Quantitative Analysis of the Antiviral Activity of CD8+ T Cells from Human Immunodeficiency Virus-Positive Asymptomatic Patients with Different Rates of CD4+ T-Cell Decrease

Rosângela Salerno-Gonçalves, Wei Lu, and Jean-Marie Andrieu*

Laboratoire d'Oncologie et Virologie Moleculaire, Faculté Necker, Hôpital Laennec, 75340 Paris Cedex 07, France

Received 5 January 2000/Accepted 21 April 2000

We have measured in 22 asymptomatic human immunodeficiency virus type 1-infected patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4+ T cells homogeneously superinfected by the same dose of a non-syncytium-inducing virus in the presence or in the absence of autologous CD8+ T cells. We demonstrated that the antiviral activity of CD8+ T cells was highly predictive of the rate of peripheral CD4+ T-cell decline.

* Corresponding author. Mailing address: Laboratoire d'Oncologie et Virologie Moleculaire, Faculté Necker, Hôpital Laennec, 42 rue de Sèvres, 75340 Paris Cedex 07, France. Phone: 33 1 44 39 64 07. Fax: 33 1 44 39 64 65. E-mail: cancero.laennec{at}lnc.ap-hop-paris.fr.

Journal of Virology, July 2000, p. 6648-6651, Vol. 74, No. 14
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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