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Journal of Virology, July 2000, p. 6227-6229, Vol. 74, No. 13
0022-538X/00/$04.00+0
Respiratory Syncytial Virus G and/or SH
Glycoproteins Modify CC and CXC Chemokine mRNA Expression in the
BALB/c Mouse
Ralph A.
Tripp,*
Les
Jones, and
Larry J.
Anderson
Division of Viral and Rickettsial Diseases,
National Center of Infectious Diseases, Centers for Disease Control
and Prevention, Atlanta, Georgia 30333
Received 18 January 2000/Accepted 11 April 2000
Chemokine mRNA expression by pulmonary leukocytes following
infection of BALB/c mice with two strains of respiratory syncytial virus (RSV) and one strain of parainfluenza virus type 3 (PIV-3) was
determined. The results suggest that RSV G and/or SH proteins inhibit
early MIP-1
, MIP-1
, MIP-2, MCP-1, and IP-10 mRNA expression. TCA-3 mRNA expression was found to be increased during PIV-3 infection.
*
Corresponding author. Mailing address: Centers for
Disease Control and Prevention, 1600 Clifton Rd., MS G09, Atlanta, GA
30333. Phone: (404) 639-3427. Fax: (404) 639-1307. E-mail:
rgt3{at}cdc.gov.
Journal of Virology, July 2000, p. 6227-6229, Vol. 74, No. 13
0022-538X/00/$04.00+0
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