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Journal of Virology, July 2000, p. 6178-6185, Vol. 74, No. 13
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Variability and Immunogenicity of Caprine Arthritis-Encephalitis Virus Surface Glycoprotein

S. Valas,1,* C. Benoit,1 C. Baudry,1 G. Perrin,1 and R. Z. Mamoun2

AFSSA-Niort, Laboratoire de Recherches Caprines, F-79012 Niort Cedex,1 and Laboratoire Rétrovirus et Thérapie, INSERM U443, Université Victor Segalen Bordeaux 2, F-33076 Bordeaux Cedex,2 France

Received 3 February 2000/Accepted 29 March 2000

The complete surface glycoprotein (SU) nucleotide sequences of three French isolates of caprine arthritis-encephalitis virus (CAEV) were determined and compared with those of previously described isolates: three American isolates and one French isolate. Phylogenetic analyses revealed the existence of four distinct and roughly equidistant evolutionary CAEV subtypes. Four conserved and five variable domains were identified in the SU. The fine specificities of antibodies produced against these domains during natural infection were examined using a pepscan analysis. Nine immunogenic segments were delineated throughout the conserved and variable domains of SU, two of them corresponding to conserved immunodominant epitopes. Antigenic determinants which may be involved in the immunopathogenic process induced by CAEV were identified. These results also provide sensitive and specific antigen peptides for the serological detection and differentiation of CAEV and visna/maedi virus infections.

* Corresponding author. Mailing address: AFSSA-Niort, Laboratoire de Recherches Caprines, B.P. 3081, 60 rue de Pied de Fond, F-79012 Niort Cedex, France. Phone: (33) 5 49 79 61 28. Fax: (33) 5 49 79 42 19. E-mail: s.valas{at}niort.afssa.fr.

Journal of Virology, July 2000, p. 6178-6185, Vol. 74, No. 13
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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