JVI Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meite, M.
Right arrow Articles by Coutelier, J.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meite, M.
Right arrow Articles by Coutelier, J.-P.

 Previous Article  |  Next Article 

Journal of Virology, July 2000, p. 6045-6049, Vol. 74, No. 13
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Exacerbation of Autoantibody-Mediated Hemolytic Anemia by Viral Infection

Mory Meite,1,dagger Sabine Léonard,1,Dagger Mohammed El Azami El Idrissi,1,§ Shozo Izui,2 Pierre L. Masson,1 and Jean-Paul Coutelier1,*

Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, 1200 Brussels, Belgium,1 and Department of Pathology, Centre Médical Universitaire, Université de Genève, Geneva, Switzerland2

Received 22 November 1999/Accepted 29 March 2000

Strong enhancement of the pathogenicity of an antierythrocyte monoclonal antibody was observed after infection of mice with lactate dehydrogenase-elevating virus. While injection of the antierythrocyte antibody alone induced only moderate anemia, concomitant infection with this virus, which is harmless in most normal mice, led to a dramatic drop in the hematocrit and to death of infected animals. In vitro and in vivo analyses showed a dramatic increase in the ability of macrophages from infected mice to phagocytose antibody-coated erythrocytes. These results indicate that viruses can trigger the onset of autoimmune disease by enhancing the pathogenicity of autoantibodies. They may explain how unrelated viruses could be implicated in the etiology of autoantibody-mediated autoimmune diseases.

* Corresponding author. Mailing address: Unit of Experimental Medicine, UCL MEXP 7430, Av. Hippocrate 74, B-1200 Bruxelles, Belgium. Phone: 32 2 764 7437. Fax: 32 2 764 7430. E-mail: coutelier{at}mexp.ucl.ac.be.

dagger Present address: Service d'hématologie et d'immunologie, CHU de Yopougon, Abidjan 21, Côte d'Ivoire.

Dagger Present address: 4845 Jalhay, Belgium.

§ Present address: Department of Microbiology, University of Illinois, Chicago, IL 60612.

Journal of Virology, July 2000, p. 6045-6049, Vol. 74, No. 13
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2000 by the American Society for Microbiology. All rights reserved.