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Journal of Virology, June 2000, p. 5470-5476, Vol. 74, No. 12
Unité des Virus Lents, CNRS URA
1930,1 and Unité d'Immunité
Cellulaire Antivirale,2 Institut Pasteur,
75724 Paris Cedex 15, France
Received 8 November 1999/Accepted 20 March 2000
H-2b mice are resistant to persistent
infection of the central nervous system by Theiler's virus. They clear
the infection 7 to 10 days after intracranial inoculation. Resistance
maps to the H-2D gene and not to the H-2K gene
and is associated with a potent antiviral cytotoxic T-lymphocyte (CTL)
response. We used H-2b mice in which the
H-2D or the H-2K gene had been inactivated to
dissect the respective roles of these genes in resistance. We report
that H-2D
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
H-2Db
/
Mice Are Susceptible to
Persistent Infection by Theiler's Virus



/
but not
H-2K
/
mice were susceptible to persistent
infection. Furthermore, whereas H-2K
/
mice mounted a vigorous virus-specific CTL response, similar to that of
control C57BL/6 mice, the CTL response of
H-2D
/
mice was nil or minimal. Using target
cells transfected with the H-2Db or the
H-2Kb gene, we showed that the
H-2K-restricted CTL response against the virus was minimal
in H-2D
/
mice. These results demonstrate
that the H-2Db and
H-2Kb genes play nonredundant roles in the
resistance to this persistent infection.
*
Corresponding author. Mailing address: Unité des
Virus Lents, CNRS URA 1930, Institut Pasteur, 28, rue du Dr. Roux,
75724 Paris Cedex 15, France. Phone: 33(0)1 45 68 87 70. Fax: 33(0)1 40 61 31 67. E-mail: mbrahic{at}pasteur.fr.
Present address: Fédération de Neurologie,
Hôpital de la Pitié-Salpêtrière, 75651 Paris
Cedex 13, France.
Present address: McKinsey & Company, Inc., 80538 Munich, Germany.
§
Present address: Department of Immunology, Division of
Investigative Science, ICSM Chelsea & Westminster Hospital, London SW10
9NH, United Kingdom.
Present address: Centre d'Immunologie de Marseille-Luminy, 13288 Marseille Cedex 9, France.
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