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Journal of Virology, June 2000, p. 5385-5387, Vol. 74, No. 11
0022-538X/00/$04.00+0

A Single Amino Acid Change in the Murine Leukemia Virus Capsid Gene Responsible for the Fv1nr Phenotype

Yong Tae Jung and Christine A. Kozak*

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Received 12 January 2000/Accepted 15 March 2000

The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.

* Corresponding author. Mailing address: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Building 4, Room 329, Bethesda, MD 20892-0460. Phone: (301) 496-0972. Fax: (301) 480-2808. E-mail: ckozak{at}nih.gov.

Journal of Virology, June 2000, p. 5385-5387, Vol. 74, No. 11
0022-538X/00/$04.00+0


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