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Journal of Virology, June 2000, p. 5347-5351, Vol. 74, No. 11
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Human Immunodeficiency Virus Type 1 Coreceptor Preferences Determine Target T-Cell Depletion and Cellular Tropism in Human Lymphoid Tissue

Jean-Charles Grivel,1 Michael L. Penn,2 Daniel A. Eckstein,2 Birgit Schramm,2 Roberto F. Speck,2 Nancy W. Abbey,3 Brian Herndier,3 Leonid Margolis,1,* and Mark A. Goldsmith2,4,*

Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892,1 and Gladstone Institute of Virology and Immunology,2 and Departments of Medicine4 and Pathology,3 School of Medicine, University of California at San Francisco, San Francisco, California 94141-9100

Received 22 July 1999/Accepted 25 February 2000

The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4+ T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor-expressing CD4+ lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.

* Corresponding author. Mailing address for Mark A. Goldsmith: Gladstone Institute of Virology and Immunology, P.O. Box 419100, San Francisco, CA 94141-9100. Phone: (415) 695-3775. Fax: (415) 695-1364. E-mail: mgoldsmith{at}gladstone.ucsf.edu. Mailing address for Leonid Margolis: N.I.H., Bldg. 10, Rm. 10D14, Bethesda, MD 20892. Phone: (301) 594-2476. Fax: (301) 480-0857. E-mail: margolis{at}helix.nih.gov.

Journal of Virology, June 2000, p. 5347-5351, Vol. 74, No. 11
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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