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Journal of Virology, May 2000, p. 4919-4928, Vol. 74, No. 10
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of Two Divergent Lineages of Macaque Rhadinoviruses Related to Kaposi's Sarcoma-Associated Herpesvirus

Emily R. Schultz,1,dagger George W. Rankin Jr.,1,Dagger Marie-Pierre Blanc,1 Brian W. Raden,1 Che-Chung Tsai,2 and Timothy M. Rose1,*

Department of Pathobiology, School of Public Health and Community Medicine,1 and Washington Regional Primate Research Center,2 University of Washington, Seattle, Washington 98195

Received 17 November 1999/Accepted 3 February 2000

We have cloned and characterized the entire DNA polymerase gene and flanking regions from Kaposi's sarcoma-associated herpesvirus (KSHV) and two closely related macaque homologs of KSHV, retroperitoneal fibromatosis-associated herpesvirus-Macaca nemestrina (RFHVMn) and -Macaca mulatta (RFHVMm). We have also identified and partially characterized the corresponding genomic region of another KSHV-like herpesvirus, provisionally named "M. nemestrina rhadinovirus type 2 (MneRV-2)," with close similarity to rhesus rhadinovirus (RRV). A sequence comparison of these four macaque viruses and two KSHV-like gammaherpesviruses recently identified in African green monkeys, Chlorocebus rhadinovirus types 1 and 2 (ChRV-1 and ChRV-2) reveals the presence of two distinct lineages of KSHV-like rhadinoviruses in Old World primates. The first rhadinovirus lineage consists of KSHV and its closely related homologs RFHVMn, RFHVMm, and ChRV-1, while the second more distantly related lineage consists of RRV, MneRV-2, and ChRV-2. Our findings raise the possibility of the existence of another human KSHV-like herpesvirus belonging to the second rhadinovirus lineage.

* Corresponding author. Mailing address: Department of Pathobiology, University of Washington, Box 357238, Seattle, WA 98195. Phone: (206) 616-2084. Fax: (206) 543-3873. E-mail: trose{at}u.washington.edu.

dagger Present address: High Throughput Sequencing Center, Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195.

Dagger Present address: School of Medicine, University of California, Davis, Calif.

Journal of Virology, May 2000, p. 4919-4928, Vol. 74, No. 10
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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