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Journal of Virology, May 2000, p. 4912-4918, Vol. 74, No. 10
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Human Papillomavirus Type 16 E7 Oncoprotein Represses Transcription of Human Fibronectin

Osvaldo Rey,1,2,3 Sora Lee,1 and No-Hee Park1,2,*

School of Dentistry,1 Dental and Craniofacial Research Institute,2 and Molecular Biology Institute,3 University of California at Los Angeles, Los Angeles, California 90095-1668

Received 24 November 1999/Accepted 23 February 2000

The E7 oncoprotein encoded by human papillomavirus (HPV) type 16 repressed the transcription of fibronectin, a key component of the extracellular matrix. This repression, detected in several HPV-positive nontumorigenic and tumorigenic cell lines, was abolished when the Cys-X-X-Cys repeats in E7 were disrupted.

* Corresponding author. Mailing address: UCLA School of Dentistry, 58-038 Center for Health Sciences, Los Angeles, CA 90095-1668. Phone: (310) 206-6063. Fax: (310) 794-7734. E-mail: npark{at}dent.ucla.edu.

Journal of Virology, May 2000, p. 4912-4918, Vol. 74, No. 10
0022-538X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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