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Journal of Virology, September 1999, p. 7899-7902, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Preferential Binding of Mouse Mammary Tumor Virus to B Lymphocytes

Frédéric Baribaud,1,* Annelyse Vessaz Shaw,1 Leo Scarpellino,2,3 Heidi Diggelmann,1 and Hans Acha-Orbea2,3

Institute of Microbiology, University of Lausanne, CH-1011 Lausanne,1 and Institute of Biochemistry, University of Lausanne,2 and Ludwig Institute for Cancer Research, Lausanne Branch,3 CH-1066 Epalinges, Switzerland

Received 4 March 1999/Accepted 2 June 1999

Mouse mammary tumor virus (MMTV) has been shown to preferentially infect B lymphocytes in vivo. We have used recombinant envelope-coated fluospheres and highly purified MMTV particles to study the distribution of the viral receptors on fresh mouse lymphocytes. A preferential dose-dependent binding to B lymphocytes was observed which could be competed with neutralizing antibodies. In contrast, T-lymphocyte binding remained at background levels. These results strongly suggest a higher density of viral receptor molecules on B lymphocytes than on T lymphocytes and correlate with the preferential initial infection of B lymphocytes observed in vivo.

* Corresponding author. Present address: Department of Pathology and Laboratory Medicine, 806 Abramson, 34th and Civic Center Blvd., Philadelphia, PA 19104. Phone: (215) 573-7532. Fax: (215) 573-2883. E-mail: fbaribau{at}mail.med.upenn.edu.

Journal of Virology, September 1999, p. 7899-7902, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Baribaud, F., Wirth, S., Maillard, I., Valsesia, S., Acha-Orbea, H., Diggelmann, H. (2001). Identification of Key Amino Acids of the Mouse Mammary Tumor Virus Superantigen Involved in the Specific Interaction with T-Cell Receptor V{beta} Domains. J. Virol. 75: 7453-7461 [Abstract] [Full Text]  


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