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Journal of Virology, September 1999, p. 7882-7885, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Middle T Antigen Activation of Signal Transduction Pathways Does Not Overcome p53-Mediated Growth Arrest

Joanne Doherty and Robert Freund*

Molecular and Cell Biology Program, University of Maryland, Baltimore, and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201

Received 15 April 1999/Accepted 17 May 1999

Polyomavirus middle T antigen does not overcome p53-mediated G1 arrest in mouse embryo fibroblasts. Middle T antigen still associates with the signaling molecules phosphatidylinositol 3-kinase and SHC and activates the transcriptional activity of c-Myc and AP1 in p53-arrested cells. Examination of cell cycle regulatory proteins indicated that p53 does not interfere with these mitogenic signals but acts later in the G1 phase of the cell cycle.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 West Baltimore St., Baltimore, MD 21201. Phone: (410) 706-1867. Fax: (410) 706-2129. E-mail: rfreund{at}umaryland.edu.

Journal of Virology, September 1999, p. 7882-7885, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Dey, D., Dahl, J., Cho, S., Benjamin, T. L. (2002). Induction and Bypass of p53 during Productive Infection by Polyomavirus. J. Virol. 76: 9526-9532 [Abstract] [Full Text]  
  • Gottlieb, K. A., Villarreal, L. P. (2001). Natural Biology of Polyomavirus Middle T Antigen. Microbiol. Mol. Biol. Rev. 65: 288-318 [Abstract] [Full Text]  
  • Dey, D. C., Bronson, R. P., Dahl, J., Carroll, J. P., Benjamin, T. L. (2000). Accelerated Development of Polyoma Tumors and Embryonic Lethality: Different Effects of p53 Loss on Related Mouse Backgrounds. Cell Growth Differ. 11: 231-237 [Abstract] [Full Text]  


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