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Journal of Virology, September 1999, p. 7877-7881, Vol. 73, No. 9
Department of Microbiology and
Immunology1 and Cardinal Bernardin
Cancer Center,3 Stritch School of Medicine,
Loyola University Chicago, Maywood, Illinois 60153, and
National Research Center for Environment and Health,
Institute of Clinical Molecular Biology and Tumor Genetics, D-81377
Munich, Germany2
Received 11 January 1999/Accepted 25 May 1999
A human papillomavirus type 16 E7 DNA vaccine with the open reading
frame encoding mutations in two zinc-binding motifs expressed a rapidly
degraded E7 protein. This vaccine induced a significantly stronger
E7-specific cytotoxic T-lymphocyte response and better tumor protection
in mice than did a wild-type E7 DNA vaccine expressing a stable E7 protein.
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Human Papillomavirus Type 16 E7 DNA Vaccine: Mutation in the Open
Reading Frame of E7 Enhances Specific Cytotoxic T-Lymphocyte
Induction and Antitumor Activity
*
Corresponding author. Mailing address: Department
of Microbiology and Immunology, Stritch School of Medicine,
Building 105, Room 2890, Loyola University Medical Center, 2160 South
First Ave., Maywood, IL 60153. Phone: (708) 327-3481. Fax: (708)
216-1196. E-mail: lqiao{at}luc.edu.
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