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Journal of Virology, September 1999, p. 7874-7876, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Rhesus Rhadinovirus Establishes a Latent Infection in B Lymphocytes In Vivo

Eric P. Bergquam,1 Nancy Avery,1 Stanley M. Shiigi,1 Michael K. Axthelm,1 and Scott W. Wong1,2,*

Division of Pathobiology and Immunology, Oregon Regional Primate Research Center, Beaverton, Oregon 97006,1 and Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, Oregon 972012

Received 18 March 1999/Accepted 9 June 1999

Recent DNA sequence analysis indicates that rhesus rhadinovirus (RRV) is a member of the lymphotropic gamma-2 herpesvirus family. To determine if RRV is lymphotropic, peripheral blood mononuclear cells from naturally infected monkeys were separated by immunomagnetic bead depletion and analyzed for the presence of RRV by virus isolation and nested PCR. The recovery and consistent detection of RRV in the CD20+-enriched fraction clearly demonstrates that B lymphocytes are a major site of virus persistence.

* Corresponding author. Mailing address: Division of Pathobiology and Immunology, Oregon Regional Primate Research Center, 505 N.W. 185th Ave., Beaverton, OR 97006. Phone: (503) 690-5285. Fax: (503) 690-5524. E-mail: wongs{at}ohsu.edu.

Journal of Virology, September 1999, p. 7874-7876, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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