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Journal of Virology, September 1999, p. 7866-7869, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Turnover of T Cells in Murine Gammaherpesvirus 68-Infected Mice

Ann Marie Hamilton-Easton, Jan P. Christensen, and Peter C. Doherty*

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee

Received 1 February 1999/Accepted 15 June 1999

Respiratory challenge of C57BL/6 mice with murine gammaherpesvirus 68 induces proliferation of T lymphocytes early after infection, as evidenced by incorporation of the DNA precursor bromodeoxyuridine. Using pulse-chase analysis, splenic and peripheral blood activated T lymphocytes were found to continue dividing for at least a month after the initial virus challenge. The results are in accord with the idea that T cells are stimulated for a substantial time after the acute, lytic phase of virus infection is resolved.

* Corresponding author. Mailing address: St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105. Phone: (901) 495-3470. Fax: (901) 495-3107. E-mail: peter.doherty{at}stjude.org.

Journal of Virology, September 1999, p. 7866-7869, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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