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Journal of Virology, September 1999, p. 7817-7822, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

R5 Strains of Human Immunodeficiency Virus Type 1 from Rapid Progressors Lacking X4 Strains Do Not Possess X4-Type Pathogenicity in Human Thymus

Robert D. Berkowitz,1,dagger Angélique B. van 't Wout,2,Dagger Neeltje A. Kootstra,2 Mary E. Moreno,1 Valerie D. Linquist-Stepps,1 Christopher Bare,1 Cheryl A. Stoddart,1 Hanneke Schuitemaker,2 and Joseph M. McCune1,3,*

Gladstone Institute of Virology and Immunology1 and Departments of Microbiology and Immunology and Medicine,3 University of California at San Francisco, San Francisco, California, and Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands2

Received 5 March 1999/Accepted 27 May 1999

Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.

* Corresponding author. Mailing address: Gladstone Institute of Virology and Immunology, P.O. Box 419100, San Francisco, CA 94141-9100. Phone: (415) 695-3828. Fax: (415) 826-8449. E-mail: mmccune{at}gladstone.ucsf.edu.

dagger Present address: SyStemix, Inc., Palo Alto, CA 94303.

Dagger Present address: Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195-7740.

Journal of Virology, September 1999, p. 7817-7822, Vol. 73, No. 9
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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