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Journal of Virology, August 1999, p. 7093-7095, Vol. 73, No. 8
0022-538X/99/$04.00+0

STAT6-Deficient Mice Exhibit Normal Induction of Murine AIDS and Expression of Immunoglobulin E following Infection with LP-BM5 Murine Leukemia Viruses

Herbert C. Morse III,1,* Thomas McCarty,1 Nathalia A. Giese,1 Lekidelu Taddesse-Heath,1 and Michael J. Grusby2,3

Laboratory of Immunopathology,1 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, and Department of Immunology and Infectious Diseases, Harvard School of Public Health,2 and Department of Medicine, Harvard Medical School,3 Boston, Massachusetts 02115

Received 26 February 1999/Accepted 4 May 1999

The unique Gag polyprotein of the replication-defective virus responsible for murine AIDS (MAIDS) induces B-cell activation, proliferation, and differentiation, including immunoglobulin class switch-recombination to immunoglobulin E (IgE). Secretion of IgE normally requires the serial induction of interleukin 4 (IL-4), engagement of the IL-4 receptor, activation of signal transducer and activator of transcription (STAT) 6, and induction of Ivarepsilon germline transcripts as a prelude to switching. Remarkably, expression of IgE is equivalent in normal and IL-4-deficient mice with MAIDS (Morawetz et al., J. Exp. Med. 184:1651-1661, 1996). To understand this anomaly, we studied mice with a null mutation of STAT6. Lymphoproliferation and immunodeficiency, the hallmarks of MAIDS, developed with comparable kinetics and degree in normal and mutant mice. In addition, serum IgE levels were indistinguishable in mice of either genotype. We conclude that B cells from mice with MAIDS activate unique IL-4- and STAT6-independent signaling pathways for B-cell activation and differentiation.

* Corresponding author. Mailing address: LIP, NIAID, NIH, Building 7, Room 304, 9000 Rockville Pike, Bethesda, MD 20892-0760. Phone: (301) 496-6379. Fax: (301) 402-0077. E-mail: hmorse{at}atlas.niaid.nih.gov.

Journal of Virology, August 1999, p. 7093-7095, Vol. 73, No. 8
0022-538X/99/$04.00+0


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