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Journal of Virology, August 1999, p. 7070-7076, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Resistance of Ribosomal Protein mRNA Translation to Protein Synthesis Shutoff Induced by Poliovirus

Beatrice Cardinali,1 Lucia Fiore,2 Nadia Campioni,1 Alessandra De Dominicis,1 and Paola Pierandrei-Amaldi1,*

Istituto di Biologia Cellulare CNR,1 and Laboratorio di Virologia, Istituto Superiore di Sanita',2 Rome, Italy

Received 3 February 1999/Accepted 27 April 1999

Poliovirus infection induces an overall inhibition of host protein synthesis, although some mRNAs continue to be translated, suggesting different translation requirements for cellular mRNAs. It is known that ribosomal protein mRNAs are translationally regulated and that the phosphorylation of ribosomal protein S6 is involved in the regulation. Here, we report that the translation of ribosomal protein mRNAs resists poliovirus infection and correlates with an increase in p70s6k activity and phosphorylation of ribosomal protein S6.

* Corresponding author. Mailing address: Istituto di Biologia Cellulare CNR, Viale Marx 43, 00137 Rome, Italy. Phone: 39-06-86090353. Fax: 39-06-8273287. E-mail: pierandrei{at}ibc.rm.cnr.it.

Journal of Virology, August 1999, p. 7070-7076, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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