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Journal of Virology, August 1999, p. 7061-7064, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Integration Machinery of ZAM, a Retroelement from Drosophila melanogaster, Acts as a Sequence-Specific Endonuclease

Pascal Leblanc, Bernard Dastugue, and Chantal Vaury*

Unité INSERM U384, 63001 Clermont-Ferrand, France

Received 18 December 1998/Accepted 7 May 1999

Retroviruses and retrotransposons insert into the host genome with no obvious sequence specificity. We examined the target sites of the retroelement ZAM by sequencing each host-ZAM junction in the genome of Drosophila melanogaster. Our overall data provide compelling evidence that ZAM integration machinery recognizes and leads to ZAM insertion into the sequence 5'-GCGCGCg-3'. This unique property of ZAM will facilitate the development of new tools to study the integration process of retroelements.

* Corresponding author. Mailing address: Unité INSERM U384, 28 Place Henri Dunant, 63001 Clermont-Ferrand, France. Phone: 33 4 73 60 80 24. Fax: 33 4 73 27 61 32. E-mail: chantal.vaury{at}inserm.u-clermont1.fr.

Journal of Virology, August 1999, p. 7061-7064, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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