This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spector, S. A.
Right arrow Articles by Stempien, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spector, S. A.
Right arrow Articles by Stempien, M. J.

 Previous Article  |  Next Article 

Journal of Virology, August 1999, p. 7027-7030, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Cytomegalovirus (CMV) DNA Load Is an Independent Predictor of CMV Disease and Survival in Advanced AIDS

Stephen A. Spector,1,2,3,* Karen Hsia,1 Michael Crager,4 Marshall Pilcher,1 Sheila Cabral,1 and Mary Jean Stempien4

Department of Pediatrics,1 Center for Molecular Genetics,2 and Center for AIDS Research,3 University of California, San Diego, La Jolla, and Roche Global Development, Palo Alto,4 California

Received 30 October 1998/Accepted 20 April 1999

The impact of cytomegalovirus (CMV) on human immunodeficiency virus type 1 (HIV-1) disease progression has been controversial. In this study, we sought to determine if CMV viral load is independent of HIV-1 viral load in predicting CMV disease and survival. Our findings indicate that in patients with advanced AIDS, CMV DNA load is an independent marker of CMV disease and survival and is more predictive than HIV-1 RNA load. Moreover, patients who respond to preemptive therapy with oral ganciclovir, with resulting undetectable levels of CMV DNA, in their plasma, have a significantly lower risk of developing CMV disease and higher rates of survival, despite stable or increasing HIV-1 RNA loads. These data provide support for CMV as an independent risk factor for mortality in persons with advanced AIDS and further suggest that effective preemptive therapy for CMV can improve patient survival rates.

* Corresponding author. Mailing address: University of California, San Diego, Clinical Sciences Building, 9500 Gilman Dr., La Jolla, CA 92093-0672. Phone: (858) 534-7170. Fax: (858) 534-7411. E-mail: saspector{at}ucsd.edu.

Journal of Virology, August 1999, p. 7027-7030, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Wolff, D. J., Heaney, D. L., Neuwald, P. D., Stellrecht, K. A., Press, R. D. (2009). Multi-Site PCR-Based CMV Viral Load Assessment-Assays Demonstrate Linearity and Precision, but Lack Numeric Standardization: A Report of the Association for Molecular Pathology. J. Mol. Diagn. 11: 87-92 [Abstract] [Full Text]  
  • Mavinakere, M. S., Williamson, C. D., Goldmacher, V. S., Colberg-Poley, A. M. (2006). Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation. J. Virol. 80: 6771-6783 [Abstract] [Full Text]  
  • Wirgart, B. Z., Andersson, P., Grillner, L. (2005). Evaluation of the ReSSQ Assay in Relation to the COBAS AMPLICOR CMV MONITOR Test and an In-House Nested PCR Method for Detection of Cytomegalovirus DNA. J. Clin. Microbiol. 43: 4057-4063 [Abstract] [Full Text]  
  • Boeckh, M., Huang, M., Ferrenberg, J., Stevens-Ayers, T., Stensland, L., Nichols, W. G., Corey, L. (2004). Optimization of Quantitative Detection of Cytomegalovirus DNA in Plasma by Real-Time PCR. J. Clin. Microbiol. 42: 1142-1148 [Abstract] [Full Text]  
  • Caliendo, A. M., Yen-Lieberman, B., Baptista, J., Andersen, J., Crumpacker, C., Schuurman, R., Spector, S. A., Bremer, J., Lurain, N. S. (2003). Comparison of Molecular Tests for Detection and Quantification of Cell-Associated Cytomegalovirus DNA. J. Clin. Microbiol. 41: 3509-3513 [Abstract] [Full Text]  
  • Kaur, A., Kassis, N., Hale, C. L., Simon, M., Elliott, M., Gomez-Yafal, A., Lifson, J. D., Desrosiers, R. C., Wang, F., Barry, P., Mach, M., Johnson, R. P. (2003). Direct Relationship between Suppression of Virus-Specific Immunity and Emergence of Cytomegalovirus Disease in Simian AIDS. J. Virol. 77: 5749-5758 [Abstract] [Full Text]  
  • Boeckh, M., Leisenring, W., Riddell, S. R., Bowden, R. A., Huang, M.-L., Myerson, D., Stevens-Ayers, T., Flowers, M. E. D., Cunningham, T., Corey, L. (2003). Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. Blood 101: 407-414 [Abstract] [Full Text]  
  • Boom, R., Sol, C. J. A., Schuurman, T., van Breda, A., Weel, J. F. L., Beld, M., ten Berge, I. J. M., Wertheim-van Dillen, P. M. E, de Jong, M. D. (2002). Human Cytomegalovirus DNA in Plasma and Serum Specimens of Renal Transplant Recipients Is Highly Fragmented. J. Clin. Microbiol. 40: 4105-4113 [Abstract] [Full Text]  
  • Sequar, G., Britt, W. J., Lakeman, F. D., Lockridge, K. M., Tarara, R. P., Canfield, D. R., Zhou, S.-S., Gardner, M. B., Barry, P. A. (2002). Experimental Coinfection of Rhesus Macaques with Rhesus Cytomegalovirus and Simian Immunodeficiency Virus: Pathogenesis. J. Virol. 76: 7661-7671 [Abstract] [Full Text]  
  • Griffiths, P. D. (2002). The treatment of cytomegalovirus infection. J Antimicrob Chemother 49: 243-253 [Abstract] [Full Text]  
  • Caliendo, A. M., Schuurman, R., Yen-Lieberman, B., Spector, S. A., Andersen, J., Manjiry, R., Crumpacker, C., Lurain, N. S., Erice, A. (2001). Comparison of Quantitative and Qualitative PCR Assays for Cytomegalovirus DNA in Plasma. J. Clin. Microbiol. 39: 1334-1338 [Abstract] [Full Text]  
  • Emery, V C (2001). Investigation of CMV disease in immunocompromised patients. J. Clin. Pathol. 54: 84-88 [Abstract] [Full Text]  
  • Deayton, J. R (2000). Is cytomegalovirus viraemia a useful tool in managing CMV disease?. Sex. Transm. Infect. 76: 342-344 [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»