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Journal of Virology, August 1999, p. 6992-7000, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Adenovirus-Mediated Gene Expression In Vivo Is Enhanced by the Antiapoptotic Bcl-2 Gene

Guadalupe Bilbao,1 Juan L. Contreras,2 Huang-Ge Zhang,3 M. Joyce Pike,4 Ken Overturf,1 Galina Mikheeva,1 Victor Krasnykh,1 and David T. Curiel1,*

Gene Therapy Center,1 Transplant Center, Department of Surgery,2 Department of Medicine,3 and Comprehensive Cancer Center,4 University of Alabama at Birmingham, Birmingham, Alabama 35294

Received 4 January 1999/Accepted 10 May 1999

An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.

* Corresponding author. Mailing address: Gene Therapy Center, 1824 6th Ave. South, Rm. WTI 620, Birmingham, AL 35294. Phone: (205) 934-8627. Fax: (205) 975-7476. E-mail: david.curiel{at}ccc.uab.edu.

Journal of Virology, August 1999, p. 6992-7000, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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