Association between Virus-Specific Cytotoxic T-Lymphocyte and Helper Responses in Human Immunodeficiency Virus Type 1 Infection

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Journal of Virology, August 1999, p. 6715-6720, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Association between Virus-Specific Cytotoxic T-Lymphocyte and Helper Responses in Human Immunodeficiency Virus Type 1 Infection

Spyros A. Kalams,¹^,^* S. P. Buchbinder,² E. S. Rosenberg,¹ J. M. Billingsley,¹ D. S. Colbert,² N. G. Jones,¹ A. K. Shea,¹ A. K. Trocha,¹ and B. D. Walker¹

Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114,¹ and AIDS Office, Department of Public Health, San Francisco, California 94140²

Received 29 December 1998/Accepted 3 May 1999

Cellular immune responses are thought to be an important antiviral host defense, but the relationship between virus-specificT-helper and cytotoxic-T-lymphocyte (CTL) responses has not beendefined. To investigate a potential link between these responses,we examined functional human immunodeficiency virus type 1 (HIV-1)-specificmemory CTL precursor frequencies and p24-specific proliferativeresponses in a cohort of infected untreated persons with a widerange of viral loads and CD4 cell counts. Levels of p24-specificproliferative responses positively correlated with levels of Gag-specificCTL precursors and negatively correlated with levels of plasmaHIV-1 RNA. These data linking the levels of HIV-specific CTL withvirus-specific helper cell function during chronic viral infectionprovide cellular immunologic parameters to guide therapeutic andprophylactic vaccinedevelopment.

^* Corresponding author. Mailing address: Massachusetts General Hospital, AIDS Research Center, 149 13th St., Rm. 5217, Charlestown,MA 02129. Phone: (617) 724-4958. Fax: (617) 726-4691. E-mail:kalams{at}helix.mgh.harvard.edu.

Journal of Virology, August 1999, p. 6715-6720, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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