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Journal of Virology, August 1999, p. 6590-6597, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Induction of Th-1 and Th-2 Responses by Respiratory Syncytial Virus Attachment Glycoprotein Is Epitope and Major Histocompatibility Complex Independent

Anon Srikiatkhachorn,1,2,* Wilbur Chang,1,3 and Thomas J. Braciale1,3,4,*

The Beirne B. Carter Center for Immunology Research1 and the Departments of Pediatrics,2 Microbiology,3 and Pathology,4 University of Virginia Health Sciences Center, Charlottesville, Virginia 22908

Received 19 January 1999/Accepted 7 May 1999

In BALB/c mice, sensitization to respiratory syncytial virus (RSV) attachment (G) glycoprotein leads to the development of lung eosinophilia upon challenge infection with RSV, a pathology indicative of a strong in vivo induction of a Th-2-type response. In this study, we found that a strong, RSV G-specific, Th-1-type cytokine response occurred simultaneously with a Th-2-type response in G-primed mice after RSV challenge. Both Th-1 and Th-2 effector CD4+ T cells recognized a single immunodominant site on this protein, implying that the differentiation of memory CD4+ T cells along the Th-1 or Th-2 effector pathway was independent of the epitope specificity of the T cells. A similar observation was made in G-primed H-2b haplotype mice after RSV challenge, further suggesting that this process is not dependent on the peptide epitope presented. On the other hand, genes mapping to loci outside of the major histocompatibility complex region are crucial regulators of the development of a Th-2-type response and lung eosinophilia. The implication of these findings for the immune mechanisms underlying the pathogenesis of RSV is discussed.

* Corresponding author. Mailing address for Anon Srikiatkhachorn: Department of Pulmonary Medicine and Allergy, Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229-3039. Phone: (513) 636-3433. Fax: (513) 636-3310. E-mail: srika0{at}chmcc.org. Mailing address for Thomas J. Braciale: Beirne B. Carter Center for Immunology Research, University of Virginia Hospital, MR4, Room 4021, Charlottesville, VA 22908. Phone: (804) 924-9233. Fax: (804) 924-1221. E-mail: tjbzr{at}Virginia.EDU.

Journal of Virology, August 1999, p. 6590-6597, Vol. 73, No. 8
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.