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Journal of Virology, July 1999, p. 6191-6196, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Reappearance of Founder Virus Sequence in Human Immunodeficiency Virus Type 1-Infected Patients

Annika C. Karlsson,1,* Hans Gaines,2,3 Matti Sällberg,1 Stefan Lindbäck,2 and Anders Sönnerborg1,2

Divisions of Clinical Virology1 and Infectious Diseases,2 Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, and the Swedish Institute for Infectious Disease Control,3 Stockholm, Sweden

Received 5 November 1998/Accepted 9 April 1999

Different patterns of temporal evolution in human immunodeficiency virus type 1 V3 and p17 regions are described for eight patients studied during the first years following primary infection. In samples from three patients, a rapid replacement of the major sequence occurred but the original sequence reappeared later simultaneously with clinical deterioration and increased plasma viral load.

* Corresponding author. Mailing address: Division of Clinical Virology, F68, Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge/Stockholm, Sweden. Phone: 46 8 585 87952. Fax: 46 8 585 87933. E-mail: Annika.Karlsson{at}impi.ki.se.

Journal of Virology, July 1999, p. 6191-6196, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.