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Journal of Virology, July 1999, p. 6182-6187, Vol. 73, No. 7
Institute of Medical Microbiology,
Received 28 December 1998/Accepted 30 March 1999
We have investigated the antigenicity of the C- and N-terminal
halves of pIX of human adenovirus types 2 and 3 (Ad2 and Ad3) as well
as their orientations in virions. We found that only the C-terminal
halves of Ad2 pIX and Ad3 pIX reacted in a subgenus-specific manner by
enzyme-linked immunosorbent assay and immunoblot analysis. Based on
immunoelectron microscopy experiments, pIX in viral capsids appears to
be positioned such that the C-terminal part of pIX constitutes the
surface domain whereas the N terminus of the protein makes up the
internal domain in icosahedral Ad capsids.
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
The Subgenus-Specific C-Terminal Region of Protein
IX Is Located on the Surface of the Adenovirus Capsid

*
Corresponding author. Mailing address: Abteilung
Virologie, Institut für Medizinische Mikrobiologie,
Martin-Luther-Str. 6, D-17487 Greifswald, Germany. Phone: 49-(0) 3834 865567. Fax: 49-(0) 3834 865568. E-mail:
seidel{at}rz.uni-greifswald.de.
Present address: Institute for Genetic Medicine and Department of
Biochemistry and Molecular Biology, USC School of Medicine, Los
Angeles, CA 90033.
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