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Journal of Virology, July 1999, p. 6136-6140, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Identification of Human Herpesvirus 8-Specific Cytotoxic T-Cell Responses

Mohamed Osman,1,2 Toru Kubo,2 Jasjit Gill,3 Frank Neipel,4 Marion Becker,5 Geoffrey Smith,5 Robin Weiss,1 Brian Gazzard,3 Chris Boshoff,1,* and Frances Gotch2,*

Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany,4 and Department of Genitourinary Medicine3 and Department of Immunology,2 Chelsea and Westminster Hospital, Imperial College School of Medicine, and Departments of Oncology and Molecular Pathology, Royal Free and University College Medical School, University College London,1 London, and Dunn School of Pathology, University of Oxford, Oxford,5 United Kingdom

Received 28 January 1999/Accepted 26 March 1999

Human herpesvirus 8 (HHV-8) (or Kaposi's sarcoma-associated herpesvirus) is implicated in the etiopathogenesis of Kaposi's sarcoma (KS) and certain lymphoproliferations. The introduction of more effective therapies to treat human immunodeficiency virus infection has led to a decline in the incidence of KS and also in the resolution of KS in those already affected. This suggests that cellular immune responses including cytotoxic T lymphocytes (CTLs) could play a vital role in the control of HHV-8 infection and in KS pathogenesis. Here we elucidate HLA class I-restricted, HHV-8-specific cellular immune responses that could be important in the control of HHV-8 infection and subsequent tumor development. We show the presence of CTLs against HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in infected individuals.

* Corresponding author. Mailing address for Chris Boshoff: Department of Oncology, 91 Riding House St., University College London, London W1P 6BT, United Kingdom. Phone: 44-171-504-9557. Fax: 44-171-504-9555. E-mail: c.boshoff{at}ucl.ac.uk. Mailing address for Frances Gotch: Department of Immunology, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom. Phone: 44-181-746-8257. Fax: 44-181-746-5997. E-mail: f.gotch{at}ic.ac.uk.

Journal of Virology, July 1999, p. 6136-6140, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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