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Journal of Virology, July 1999, p. 6136-6140, Vol. 73, No. 7
Institut für Klinische und Molekulare
Virologie, Universität Erlangen-Nürnberg, D-91054 Erlangen,
Germany,4 and Department of
Genitourinary Medicine3 and Department
of Immunology,
Received 28 January 1999/Accepted 26 March 1999
Human herpesvirus 8 (HHV-8) (or Kaposi's sarcoma-associated
herpesvirus) is implicated in the etiopathogenesis of Kaposi's sarcoma
(KS) and certain lymphoproliferations. The introduction of more
effective therapies to treat human immunodeficiency virus infection has
led to a decline in the incidence of KS and also in the resolution of
KS in those already affected. This suggests that cellular immune
responses including cytotoxic T lymphocytes (CTLs) could play a vital
role in the control of HHV-8 infection and in KS pathogenesis. Here we
elucidate HLA class I-restricted, HHV-8-specific cellular immune
responses that could be important in the control of HHV-8 infection and
subsequent tumor development. We show the presence of CTLs against
HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in
infected individuals.
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Identification of Human Herpesvirus 8-Specific
Cytotoxic T-Cell Responses
*
Corresponding author. Mailing address for Chris
Boshoff: Department of Oncology, 91 Riding House St., University
College London, London W1P 6BT, United Kingdom. Phone: 44-171-504-9557. Fax: 44-171-504-9555. E-mail: c.boshoff{at}ucl.ac.uk.
Mailing address for Frances Gotch: Department of Immunology, Chelsea
and Westminster Hospital, London SW10 9NH, United Kingdom. Phone:
44-181-746-8257. Fax: 44-181-746-5997. E-mail:
f.gotch{at}ic.ac.uk.
Journal of Virology, July 1999, p. 6136-6140, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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