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Journal of Virology, July 1999, p. 6136-6140, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Identification of Human Herpesvirus 8-Specific
Cytotoxic T-Cell Responses
Mohamed
Osman,1,2
Toru
Kubo,2
Jasjit
Gill,3
Frank
Neipel,4
Marion
Becker,5
Geoffrey
Smith,5
Robin
Weiss,1
Brian
Gazzard,3
Chris
Boshoff,1,* and
Frances
Gotch2,*
Institut für Klinische und Molekulare
Virologie, Universität Erlangen-Nürnberg, D-91054 Erlangen,
Germany,4 and Department of
Genitourinary Medicine3 and Department
of Immunology,2 Chelsea and Westminster
Hospital, Imperial College School of Medicine, and
Departments of Oncology and Molecular Pathology, Royal Free
and University College Medical School, University College
London,1 London, and Dunn School of
Pathology, University of Oxford, Oxford,5 United
Kingdom
Received 28 January 1999/Accepted 26 March 1999
Human herpesvirus 8 (HHV-8) (or Kaposi's sarcoma-associated
herpesvirus) is implicated in the etiopathogenesis of Kaposi's sarcoma
(KS) and certain lymphoproliferations. The introduction of more
effective therapies to treat human immunodeficiency virus infection has
led to a decline in the incidence of KS and also in the resolution of
KS in those already affected. This suggests that cellular immune
responses including cytotoxic T lymphocytes (CTLs) could play a vital
role in the control of HHV-8 infection and in KS pathogenesis. Here we
elucidate HLA class I-restricted, HHV-8-specific cellular immune
responses that could be important in the control of HHV-8 infection and
subsequent tumor development. We show the presence of CTLs against
HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in
infected individuals.
*
Corresponding author. Mailing address for Chris
Boshoff: Department of Oncology, 91 Riding House St., University
College London, London W1P 6BT, United Kingdom. Phone: 44-171-504-9557. Fax: 44-171-504-9555. E-mail: c.boshoff{at}ucl.ac.uk.
Mailing address for Frances Gotch: Department of Immunology, Chelsea
and Westminster Hospital, London SW10 9NH, United Kingdom. Phone:
44-181-746-8257. Fax: 44-181-746-5997. E-mail:
f.gotch{at}ic.ac.uk.
Journal of Virology, July 1999, p. 6136-6140, Vol. 73, No. 7
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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