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Journal of Virology, June 1999, p. 5225-5230, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Primary Virus Envelope Cross-Reactivity of the Broadening Neutralizing Antibody Response during Early Chronic Human Immunodeficiency Virus Type 1 Infection

Peng Fei Zhang,1 Xi Chen,1 Da Wei Fu,1,dagger Joseph B. Margolick,2 and Gerald V. Quinnan Jr.1,*

Department of Preventive Medicine and Biometrics, Division of Tropical Public Health, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814,1 and Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, Maryland 212052

Received 29 December 1998/Accepted 12 March 1999

To test the hypothesis that changing neutralizing antibody responses against human immunodeficiency virus type 1 (HIV-1) during chronic infection were a response to emergence of neutralization escape mutants, we cloned expressed and characterized envelope clones from patients in the Multicenter AIDS Cohort Study (MACS). Pseudotyped HIV-1 envelope clones obtained from differing time points were assessed for sensitivity to neutralization by using sera from different times from the same and different patients. Clones from early and late time points during chronic infection had similar neutralization sensitivity, and neutralizing antibody responses cross-reacted with early, late, and heterologous envelopes. The potential for broadly effective HIV-1 immunization is supported.

* Corresponding author. Mailing address: Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814. Phone: (301) 295-3734. Fax: (301) 295-1971. E-mail: gquinnan{at}usuhs.mil.

dagger Present address: National Vaccine and Serum Institute, Chaoyang District, Beijing, China.

Journal of Virology, June 1999, p. 5225-5230, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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