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Journal of Virology, June 1999, p. 5207-5213, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Human Immunodeficiency Virus Type 2 Produces a Defect in CD3-gamma Gene Transcripts Similar to That Observed for Human Immunodeficiency Virus Type 1

Iris Segura,1,dagger Christine Delmelle-Wibaut,1,Dagger Michel Janssens,2 Yvette Cleuter,3 Anne van den Broeke,3 Richard Kettmann,4 and Karen E. Willard-Gallo1,3,*

International Institute of Cellular and Molecular Pathology, B1200 Brussels,1 SmithKline Beecham Biologicals, B1330 Rixensart,2 Department of Molecular Biology, University of Brussels, B1640 Rhode-St.-Genèse,3 and Department of Molecular Biology, Faculty of Agronomy, Gembloux,4 Belgium

Received 28 December 1998/Accepted 1 March 1999

T cells are central players in the immune response to infectious disease, with the specificity of their responses controlled by the T-cell receptor (TCR)/CD3 complex on the cell surface. Impairment of TCR/CD3-directed CD4+ T-cell immune responses is frequently observed in individuals infected with human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). Virus replication is also regulated by T-cell activation factors, with HIV-1 and HIV-2 responding to different TCR/CD3-directed cellular pathways. We previously demonstrated that HIV-1 infection of the human interleukin-2-dependent CD4+ T-cell line WE17/10 abrogates TCR/CD3 function and surface expression by a specific loss of CD3-gamma gene transcripts. In this study, we show that HIV-2 provokes the same molecular defect in CD3-gamma gene transcripts, resulting in a similar but delayed progressive loss of TCR/CD3 surface expression after infection.

* Corresponding author. Present address: Department of Molecular Biology, University of Brussels, rue des Chevaux, 67, B1640 Rhode-St.-Genèse, Belgium. Phone: (32) 2/650-9826. Fax: (32) 10/22.91.62 or 2/650-9839. E-mail: kwillard{at}dbm.ulb.ac.be.

dagger Present address: Centro Internacionale de Investigaciones Médicas, Cali, Colombia.

Dagger Present address: SmithKline Beecham Biologicals, B1330 Rixensart, Belgium.

Journal of Virology, June 1999, p. 5207-5213, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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