Previous Article | Next Article ![]()
Journal of Virology, June 1999, p. 5201-5206, Vol. 73, No. 6
Unité des Arbovirus et Virus des
Fièvres Hémorragiques,
Received 3 December 1998/Accepted 17 March 1999
We investigated the ability of dengue virus to invade human primary
Kupffer cells and to complete its life cycle. The virus effectively
penetrated Kupffer cells, but the infection did not result in any viral
progeny. Dengue virus-replicating Kupffer cells underwent apoptosis and
were cleared by phagocytosis. Infected Kupffer cells produced soluble
mediators that could intervene in dengue virus pathogenesis.
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Infection of Primary Cultures of Human Kupffer
Cells by Dengue Virus: No Viral Progeny Synthesis, but Cytokine
Production Is Evident
*
Corresponding author. Mailing address: Unité des
Arbovirus et Virus des Fièvres Hémorragiques, Institut
Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone:
33-1-45688723. Fax: 33-1-40613774. E-mail:
vdeubel{at}pasteur.fr.
Journal of Virology, June 1999, p. 5201-5206, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
This article has been cited by other articles:
| J. Bacteriol. | Mol. Cell. Biol. | Microbiol. Mol. Biol. Rev. |
|---|
| Clin. Vaccine Immunol. | ALL ASM JOURNALS |
|---|