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Journal of Virology, June 1999, p. 5201-5206, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Infection of Primary Cultures of Human Kupffer Cells by Dengue Virus: No Viral Progeny Synthesis, but Cytokine Production Is Evident

Philippe Marianneau,1 Anne-Marie Steffan,2 Cathy Royer,2 Marie-Thérèse Drouet,1 D. Jaeck,3 André Kirn,2 and Vincent Deubel1,*

Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 75724 Paris Cedex 15,1 and Laboratoire de Virologie de La Faculté de Médecine, INSERM U74,2 and Centre de Chirurgie Viscérale et de Transplantation, CHU Hautepierre,3 67000 Strasbourg, France

Received 3 December 1998/Accepted 17 March 1999

We investigated the ability of dengue virus to invade human primary Kupffer cells and to complete its life cycle. The virus effectively penetrated Kupffer cells, but the infection did not result in any viral progeny. Dengue virus-replicating Kupffer cells underwent apoptosis and were cleared by phagocytosis. Infected Kupffer cells produced soluble mediators that could intervene in dengue virus pathogenesis.

* Corresponding author. Mailing address: Unité des Arbovirus et Virus des Fièvres Hémorragiques, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33-1-45688723. Fax: 33-1-40613774. E-mail: vdeubel{at}pasteur.fr.

Journal of Virology, June 1999, p. 5201-5206, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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