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Journal of Virology, June 1999, p. 5186-5190, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Modular Evolution of the Integrase Domain in the Ty3/Gypsy Class of LTR Retrotransposons

Harmit S. Malik and Thomas H. Eickbush*

Department of Biology, University of Rochester, Rochester, New York 14627-0211

Received 7 December 1998/Accepted 9 March 1999

A phylogenetic analysis of the Ty3/Gypsy group of retrotransposons identified a conserved domain (GPY/F) present in the integrases of several members of this group as well as of certain vertebrate retroviruses. The analysis suggested an evolutionary scheme for the acquisition and loss of the GPY/F domain as well as the acquisition of a chromodomain module in the integrase encoded by this group of elements that may direct targeting specificity in the host genome.

* Corresponding author. Mailing address: Department of Biology, University of Rochester, Box 270211, Rochester, NY 14627-0211. Phone: (716) 275-7247. Fax: (716) 275-2070. E-mail: eick{at}uhura.cc.rochester.edu.

Journal of Virology, June 1999, p. 5186-5190, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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