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Journal of Virology, June 1999, p. 5144-5148, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Immunohistochemical Analysis, Human Papillomavirus DNA Detection, Hormonal Manipulation, and Exogenous Gene Expression of Normal and Dysplastic Human Cervical Epithelium in Severe Combined Immunodeficiency Mice

Jason A. Taylor,1 Krishnansu Tewari,1,2 Shu Y. Liao,3 Christopher C. W. Hughes,1 and Luis P. Villarreal1,*

Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697,1 and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Irvine---Medical Center,2 and Department of Surgical Pathology, St. Joseph's Hospital,3 Orange, California 92868

Received 30 October 1998/Accepted 18 February 1999

The cervical squamocolumnar junction of normal and dysplastic human xenografts was maintained in SCID-beige mice. Dysplastic tissue maintained a dysplastic morphology, irregular pattern of keratin expression, elevated levels of cellular proliferation, and human papillomavirus type 16 and/or type 18 DNA. Hyperplastic changes of normal xenografts occurred via high-dose estrogen exposure, and through recombinant adenovirus infection, the introduction and stable expression of an exogenous gene was accomplished.

* Corresponding author. Mailing address: The Center for Viral Vector Design, Department of Molecular Biology and Biochemistry, School of Biological Sciences, Room 3232, Bio Sciences II, University of California, Irvine, Irvine, CA 92697. Phone: (949) 824-6074. Fax: (949) 824-8551. E-mail address: lpvillar{at}uci.edu.

Journal of Virology, June 1999, p. 5144-5148, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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