This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huber, S. A.
Right arrow Articles by Newell, M. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huber, S. A.
Right arrow Articles by Newell, M. K.

 Previous Article  |  Next Article 

Journal of Virology, June 1999, p. 4689-4695, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Hormonal Regulation of CD4+ T-Cell Responses in Coxsackievirus B3-Induced Myocarditis in Mice

S. A. Huber,* J. Kupperman, and M. K. Newell

Departments of Pathology and Medicine, University of Vermont, Burlington, Vermont 05405

Received 11 December 1998/Accepted 1 March 1999

Coxsackievirus B3 infection causes significant cardiac inflammation in male, but not female, B1.Tg.Ealpha mice. This gender difference in disease susceptibility correlates with selective induction of CD4+ Th1 (gamma interferon-positive) cell responses in animals with testosterone, whereas estradiol promotes preferential CD4+ Th2 (interleukin-4 positive [IL-4+]) cell responses. Differences in immune deviation of CD4+ T cells cannot be explained by variation in B7-1 or B7-2 expression. Infection significantly upregulated both molecules, but no differences were detected between estradiol- and testosterone-treated groups. Significantly increased numbers of activated (CD69+) T cells expressing the gamma delta T-cell receptor were found in male and testosterone-treated male and female mice. In vivo depletion of gamma delta + cells by using monoclonal antibodies inhibited myocarditis and resulted in a shift from a Th1 to Th2 response phenotype. Taken together, our results indicate that testosterone promotes a CD4+ Th1 cell response and myocarditis by promoting increased gamma delta + cell activation.

* Corresponding author. Mailing address: Department of Pathology, University of Vermont, 55A South Park Dr., Colchester, VT 05446. Phone: (802) 656-8944. Fax: (802) 656-8965. E-mail: shuber{at}salus.med.uvm.edu.

Journal of Virology, June 1999, p. 4689-4695, Vol. 73, No. 6
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Schweitzer, S. C., Reding, A. M., Patton, H. M., Sullivan, T. P., Stubbs, C. E., Villalobos-Menuey, E., Huber, S. A., Newell, M. K. (2006). Endogenous versus exogenous fatty acid availability affects lysosomal acidity and MHC class II expression. J. Lipid Res. 47: 2525-2537 [Abstract] [Full Text]  
  • Fuller, A. C., Kang, B., Kang, H. K., Yahikozowa, H., Dal Canto, M. C., Kim, B. S. (2005). Gender Bias in Theiler's Virus-Induced Demyelinating Disease Correlates with the Level of Antiviral Immune Responses. J. Immunol. 175: 3955-3963 [Abstract] [Full Text]  
  • Burgos, J. S., Ramirez, C., Sastre, I., Alfaro, J. M., Valdivieso, F. (2005). Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender. J. Virol. 79: 1605-1612 [Abstract] [Full Text]  
  • Reading, P. C., Moore, J. B., Smith, G. L. (2003). Steroid Hormone Synthesis by Vaccinia Virus Suppresses the Inflammatory Response to Infection. JEM 197: 1269-1278 [Abstract] [Full Text]  
  • Huber, S. A., Sartini, D., Exley, M. (2002). V{gamma}4+ T Cells Promote Autoimmune CD8+ Cytolytic T-Lymphocyte Activation in Coxsackievirus B3-Induced Myocarditis in Mice: Role for CD4+ Th1 Cells. J. Virol. 76: 10785-10790 [Abstract] [Full Text]  
  • Roberts, C. W., Walker, W., Alexander, J. (2001). Sex-Associated Hormones and Immunity to Protozoan Parasites. Clin. Microbiol. Rev. 14: 476-488 [Abstract] [Full Text]  
  • Huber, S. A., Graveline, D., Born, W. K., O'Brien, R. L. (2001). Cytokine Production by V{gamma}+-T-Cell Subsets Is an Important Factor Determining CD4+-Th-Cell Phenotype and Susceptibility of BALB/c Mice to Coxsackievirus B3-Induced Myocarditis. J. Virol. 75: 5860-5869 [Abstract] [Full Text]  
  • Han, X., Lundberg, P., Tanamachi, B., Openshaw, H., Longmate, J., Cantin, E. (2001). Gender Influences Herpes Simplex Virus Type 1 Infection in Normal and Gamma Interferon-Mutant Mice. J. Virol. 75: 3048-3052 [Abstract] [Full Text]  
  • Slifka, M. K., Pagarigan, R., Mena, I., Feuer, R., Whitton, J. L. (2001). Using Recombinant Coxsackievirus B3 To Evaluate the Induction and Protective Efficacy of CD8+ T Cells during Picornavirus Infection. J. Virol. 75: 2377-2387 [Abstract] [Full Text]  
  • Klein, S. L., Bird, B. H., Glass, G. E. (2000). Sex Differences in Seoul Virus Infection Are Not Related to Adult Sex Steroid Concentrations in Norway Rats. J. Virol. 74: 8213-8217 [Abstract] [Full Text]  
  • Henke, A., Launhardt, H., Klement, K., Stelzner, A., Zell, R., Munder, T. (2000). Apoptosis in Coxsackievirus B3-Caused Diseases: Interaction between the Capsid Protein VP2 and the Proapoptotic Protein Siva. J. Virol. 74: 4284-4290 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»