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Journal of Virology, May 1999, p. 4513-4517, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

The Human HLA-A*0201 Allele, Expressed in Hamster Cells, Is Not a High-Affinity Receptor for Adenovirus Type 5 Fiber

E. Davison,1 I. Kirby,1 T. Elliott,2 and G. Santis1,*

Department of Respiratory Medicine & Allergy, The Guy's, King's College and St. Thomas' Hospitals School of Medicine, Thomas Guy House, Guy's Hospital, London SE1 9RT,1 and Immunochemistry Laboratory, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU,2 United Kingdom

Received 19 November 1998/Accepted 9 February 1999

The coxsackie B virus and adenovirus receptor (CAR) and the major histocompatibility complex (MHC) class I alpha 2 domain have been identified as high-affinity cell receptors for adenovirus type 5 (Ad5) fiber. In this study we show that CAR but not MHC class I allele HLA-A*0201 binds to Ad5 with high affinity when expressed on hamster cells. When both receptors are coexpressed on the cell surface of hamster cells, Ad5 fiber bind to a single high-affinity receptor, which is CAR.

* Corresponding author. Mailing address: Department of Respiratory Medicine & Allergy, The Guy's, King's College and St. Thomas' Hospitals School of Medicine, Thomas Guy House, Guy's Hospital, St. Thomas St., London SE1 9RT, United Kingdom. Phone: 44-171-9552758. Fax: 44-171-4038640. E-mail: george.santis{at}kcl.ac.uk.

Journal of Virology, May 1999, p. 4513-4517, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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