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Journal of Virology, May 1999, p. 4502-4507, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Incomplete Regulation of NF-kappa B by Ikappa Balpha during Respiratory Syncytial Virus Infection in A549 Cells

Michael A. Fiedler* and Kara Wernke-Dollries

Division of Pulmonary Medicine, Children's Hospital Research Foundation, Cincinnati, Ohio 45229-3039

Received 20 October 1998/Accepted 19 January 1999

Respiratory syncytial virus (RSV) infection of airway epithelial cells results in persistent NF-kappa B activation and NF-kappa B-mediated interleukin-8 production. Previous studies in airway epithelial cells demonstrated that tumor necrosis factor alpha (TNF-alpha )-induced NF-kappa B activation is transient due to regulation by Ikappa Balpha . However, during RSV infection, Ikappa Balpha has only a partial inhibitory effect on NF-kappa B activation. Studies presented here demonstrate that neither increased Ikappa Balpha production which occurs as a result of RSV-induced NF-kappa B activation nor inhibition of proteasome-mediated Ikappa Balpha degradation results in a reversal of RSV-induced NF-kappa B activation. Thus, while manipulation of Ikappa Balpha results in reversal of TNF-alpha -induced NF-kappa B activation, manipulation of Ikappa Balpha does not result in a reversal of RSV-induced NF-kappa B activation.

* Corresponding author. Mailing address: Division of Pulmonary Medicine, Children's Hospital Research Foundation, 3333 Burnet Ave., Cincinnati, OH 45229-3039. Phone: (513) 636-6771. Fax: (513) 636-4615. E-mail: FIEDM0{at}CHMCC.ORG.

Journal of Virology, May 1999, p. 4502-4507, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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