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Journal of Virology, May 1999, p. 4489-4492, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Novel Role for E4 Region Genes in Protection of Adenovirus Vectors from Lysis by Cytotoxic T Lymphocytes

Johanne M. Kaplan,* Donna Armentano, Abraham Scaria, Lisa A. Woodworth, Sarah E. Pennington, Samuel C. Wadsworth, Alan E. Smith, and Richard J. Gregory

Genzyme Corporation, Framingham, Massachusetts 01701-9322

Received 2 December 1998/Accepted 19 February 1999

Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.

* Corresponding author. Mailing address: Genzyme Corporation, 31 New York Ave., P.O. Box 9322, Framingham, MA 01701-9322. Phone: (508) 270-2442. Fax: (508) 872-4091. E-mail: jkaplan{at}genzyme.com.

Journal of Virology, May 1999, p. 4489-4492, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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