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Journal of Virology, May 1999, p. 4461-4464, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Contribution of Virus-Receptor Interaction to Distinct Viral Proliferation of Neuropathogenic and Nonneuropathogenic Murine Leukemia Viruses in Rat Glial Cells

Sayaka Takase-Yoden* and Rihito Watanabe

Institute of Life Science, Soka University, Hachioji, Tokyo 192-8577, Japan

Received 14 September 1998/Accepted 15 January 1999

The efficiency of receptor-mediated entry of pseudotyped virus carrying the surface protein (SU) of clone A8, a neuropathogenic variant of Friend murine leukemia virus (FrMLV), to rat glial cell line F10 was 1 order of magnitude greater than that of pseudotyped virus carrying SU of nonneuropathogenic FrMLV clone 57. Introduction of the gene coding for ecotropic MLV receptor on F10 cells (F10-ecoR) into SIRC cells, which are naturally resistant to FrMLV infection, also revealed the difference in receptor recognition between the A8 and the 57 viruses. Our results show that the difference in receptor utilization between A8-SU and 57-SU only partially explains the 3-order-of-magnitude difference in proliferation between A8 and 57 viruses in F10 cells.

* Corresponding author. Mailing address: Institute of Life Science, Soka University, Tangi-cho 1-236, Hachioji, Tokyo 192-8577, Japan. Phone: (81)426-91-2375. Fax: (81)426-91-9315. E-mail: takase{at}scc1.t.soka.ac.jp.

Journal of Virology, May 1999, p. 4461-4464, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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