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Journal of Virology, May 1999, p. 4439-4442, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Oncogene Activation in Myeloid Leukemias by Graffi Murine Leukemia Virus Proviral Integration

Catherine Denicourt, Elsy Edouard, and Eric Rassart*

Laboratoire de Biologie Moléculaire, Département des Sciences Biologiques, Université du Québec à Montréal, Montréal, Québec H3C 3P8, Canada

Received 23 October 1998/Accepted 16 January 1999

The Graffi murine leukemia virus (MuLV) is a nondefective retrovirus that induces granulocytic leukemia in BALB/c and NFS mice. To identify genes involved in Graffi MuLV-induced granulocytic leukemia, tumor cell DNAs were examined for genetic alterations at loci described as common proviral integration sites in MuLV-induced myeloid, lymphoid, and erythroid leukemias. Southern blot analysis revealed rearrangements in c-myc, Fli-1, Pim-1, and Spi-1/PU.1 genes in 20, 10, 3.3, and 3.3% of the tumors tested, respectively. These results demonstrate for the first time the involvement of those genes in granulocytic leukemia.

* Corresponding author. Mailing address: Laboratoire de Biologie Moléculaire, Département des Sciences Biologiques, Université du Québec à Montréal, C.P. 8888, Succursale Centre-Ville, Montréal, Québec H3C 3P8, Canada. Phone: (514) 987-3000, ext. 3953. Fax: (514) 987-4647. E-mail: rassart.eric{at}UQAM.ca.

Journal of Virology, May 1999, p. 4439-4442, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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