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Journal of Virology, May 1999, p. 3603-3607, Vol. 73, No. 5
Rational Drug Design Laboratories,
Received 19 August 1998/Accepted 13 January 1999
It has been reported that human immunodeficiency virus type 1 (HIV-1) bound to follicular dendritic cells (FDCs) remains highly infectious to CD4+ T cells even when it forms immune
complexes with neutralizing antibody (HIV-1/IC). To elucidate
the role of FDCs in HIV-1 transmission to CD4+ T cells in
lymph nodes, we have isolated and purified FDCs from human tonsils and
examined whether the HIV-1/IC trapped on their surface is infectious to
CD4+ T cells. To our surprise, not the HIV-1/IC but the
antibody-free HIV-1 on FDCs could be transmitted to CD4+ T
cells. Furthermore, in contrast to previous studies showing that FDCs
are productively infected with HIV-1, the present study clearly
demonstrated that FDCs were not the target cells for HIV-1 infection. FDCs could capture the viral particles on their surface; however, the binding of HIV-1 to FDCs was strongly
inhibited by the presence of anti-CD54 (ICAM-1) monoclonal antibody
(MAb) and anti-CD11a (LFA-1) MAb, suggesting that the
adhesion molecules play an important role in the interaction between
HIV-1 and FDCs.
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Human Follicular Dendritic Cells Remain Uninfected and Capture
Human Immunodeficiency Virus Type 1 through CD54-CD11a
Interaction
*
Corresponding author. Mailing address: Division of
Human Retroviruses, Center for Chronic Viral Diseases, Faculty of
Medicine, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima
890-8520, Japan. Phone: 81-99-275-5930. Fax: 81-99-275-5932. E-mail: baba{at}med3.kufm.kagoshima-u.ac.jp.
Journal of Virology, May 1999, p. 3603-3607, Vol. 73, No. 5
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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