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Journal of Virology, April 1999, p. 3497-3504, Vol. 73, No. 4
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Distinct Human Immunodeficiency Virus Strains in the Bone Marrow Are Associated with the Development of Thrombocytopenia

Frosso Voulgaropoulou,1,2 Benjamin Tan,1 Marcelo Soares,3 Beatrice Hahn,3 and Lee Ratner1,2,4,*

Departments of Medicine,1 Pathology,2 and Molecular Microbiology,4 Washington University, St. Louis, Missouri 63110, and Departments of Medicine and Microbiology, University of Alabama, Birmingham, Alabama 352943

Received 9 October 1998/Accepted 14 December 1998

We analyzed bone marrow and blood from human immunodeficiency virus type 1 (HIV-1)-infected individuals and described the HIV-1 quasispecies in these cellular compartments. HIV-1 isolates from the bone marrow of thrombocytopenic patients contained distinct amino acids in the V3 loop and infected T-cell lines, implicating this virus in the development of thrombocytopenia.

* Corresponding author. Mailing address: Departments of Medicine, Pathology, and Molecular Microbiology, Box 8069, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 362-8836. Fax: (314) 747-2797. E-mail: lratner{at}imgate.wustl.edu.

Journal of Virology, April 1999, p. 3497-3504, Vol. 73, No. 4
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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