Sequence and Genomic Analysis of a Rhesus Macaque Rhadinovirus with Similarity to Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8

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Journal of Virology, April 1999, p. 3040-3053, Vol. 73, No. 4
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Sequence and Genomic Analysis of a Rhesus Macaque Rhadinovirus with Similarity to Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8

Robert P. Searles,¹ Eric P. Bergquam,¹ Michael K. Axthelm,¹ and Scott W. Wong¹^,²^,^*

Division of Pathobiology and Immunology, Oregon Health Sciences University/Oregon Regional Primate Research Center, Beaverton, Oregon 97006,¹ and Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, Oregon 97201²

Received 3 September 1998/Accepted 11 January 1999

We have sequenced the long unique region (LUR) and characterized the terminal repeats of the genome of a rhesus rhadinovirus(RRV), strain 17577. The LUR as sequenced is 131,364 bp in length,with a G+C content of 52.2% and a CpG ratio of 1.11. The genomecodes for 79 open reading frames (ORFs), with 67 of these ORFssimilar to genes found in both Kaposi's sarcoma-associated herpesvirus(KSHV) (formal name, human herpesvirus 8) and herpesvirus saimiri.Eight of the 12 unique genes show similarity to genes found inKSHV, including genes for viral interleukin-6, viral macrophageinflammatory protein, and a family of viral interferon regulatoryfactors (vIRFs). Genomic organization is essentially colinearwith KSHV, the primary differences being the number of cytokineand IRF genes and the location of the gene for dihydrofolate reductase.Highly repetitive sequences are located in positions correspondingto repetitive sequences found in KSHV. Phylogenetic analysis ofseveral ORFs supports the similarity between RRV and KSHV. Overall,the sequence, structural, and phylogenetic data combine to providestrong evidence that RRV 17577 is the rhesus macaque homolog ofKSHV.

^* Corresponding author. Mailing address: Division of Pathobiology and Immunology, Oregon Regional Primate Research Center, 505NW 185th Ave., Beaverton, OR 97006. Phone: (503) 690-5285. Fax:(503) 690-5524. E-mail: wongs{at}ohsu.edu.

Journal of Virology, April 1999, p. 3040-3053, Vol. 73, No. 4
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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