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Journal of Virology, April 1999, p. 3040-3053, Vol. 73, No. 4
Division of Pathobiology and Immunology,
Oregon Health Sciences University/Oregon Regional Primate Research
Center, Beaverton, Oregon 97006,1 and
Department of Molecular Microbiology and Immunology, Oregon
Health Sciences University, Portland, Oregon
972012
Received 3 September 1998/Accepted 11 January 1999
We have sequenced the long unique region (LUR) and characterized
the terminal repeats of the genome of a rhesus rhadinovirus (RRV),
strain 17577. The LUR as sequenced is 131,364 bp in length, with a G+C
content of 52.2% and a CpG ratio of 1.11. The genome codes for 79 open
reading frames (ORFs), with 67 of these ORFs similar to genes found in
both Kaposi's sarcoma-associated herpesvirus (KSHV) (formal name,
human herpesvirus 8) and herpesvirus saimiri. Eight of the 12 unique genes show similarity to genes found in KSHV, including
genes for viral interleukin-6, viral macrophage inflammatory protein,
and a family of viral interferon regulatory factors (vIRFs). Genomic
organization is essentially colinear with KSHV, the primary differences
being the number of cytokine and IRF genes and the location of the gene
for dihydrofolate reductase. Highly repetitive sequences
are located in positions corresponding to repetitive sequences found in
KSHV. Phylogenetic analysis of several ORFs supports the
similarity between RRV and KSHV. Overall, the sequence,
structural, and phylogenetic data combine to provide strong evidence that RRV 17577 is the rhesus macaque homolog of KSHV.
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Sequence and Genomic Analysis of a Rhesus Macaque Rhadinovirus
with Similarity to Kaposi's Sarcoma-Associated Herpesvirus/Human
Herpesvirus 8
*
Corresponding author. Mailing address: Division of
Pathobiology and Immunology, Oregon Regional Primate Research Center,
505 NW 185th Ave., Beaverton, OR 97006. Phone: (503) 690-5285. Fax: (503) 690-5524. E-mail: wongs{at}ohsu.edu.
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