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Journal of Virology, March 1999, p. 2563-2567, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Resistance of Interleukin-1beta -Deficient Mice to Fatal Sindbis Virus Encephalitis

Xiao Huan Liang,1 James E. Goldman,2 Hui Hui Jiang,1 and Beth Levine1,*

Departments of Medicine1 and Pathology,2 Columbia University College of Physicians & Surgeons, New York, New York 10032

Received 16 September 1998/Accepted 18 November 1998

Interleukin-1beta (IL-1beta ) concentrations are frequently elevated in central nervous system (CNS) viral infections, but the pathophysiologic significance of such elevations is not known. To examine the role of IL-1beta in CNS viral pathogenesis, we compared the natural histories of IL-1beta -deficient and wild-type 129 SV(ev) mice infected with a neurovirulent viral strain, neuroadapted Sindbis virus (NSV). We found that the incidence of severe paralysis and death was markedly decreased in NSV-infected IL-1beta -/- mice compared to NSV-infected wild-type mice (4 versus 88%, P < 0.001). Despite this marked difference in clinical outcome, no differences in numbers of apoptotic cells or presence of histopathologic lesions in the brains of moribund wild-type mice and those of clinically healthy IL-1beta -/- mice could be detected. These results suggest that IL-1beta deficiency is protective against fatal Sindbis virus infection by a mechanism that does not involve resistance to CNS virus-induced apoptosis or histopathology.

* Corresponding author. Mailing address: Department of Medicine, Columbia University College of Physicians & Surgeons, P & S 8-444, 630 W. 168th St., New York, NY 10032. Phone: (212) 305-7312. Fax: (212) 305-7290. E-mail: Levine{at}cuccfa.ccc.columbia.edu.

Journal of Virology, March 1999, p. 2563-2567, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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