Coxsackievirus and Adenovirus Receptor Cytoplasmic and Transmembrane Domains Are Not Essential for Coxsackievirus and Adenovirus Infection

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Journal of Virology, March 1999, p. 2559-2562, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Coxsackievirus and Adenovirus Receptor Cytoplasmic and Transmembrane Domains Are Not Essential for Coxsackievirus and Adenovirus Infection

Xianghong Wang and Jeffrey M. Bergelson^*

Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104

Received 18 September 1998/Accepted 16 November 1998

Coxsackievirus and adenovirus receptor (CAR) from which the cytoplasmic domain had been deleted and glycosylphosphatidylinositol(GPI)-anchored CAR lacking both transmembrane and cytoplasmicdomains were both capable of facilitating adenovirus 5-mediatedgene delivery and infection by coxsackievirus B3. These resultsindicate that the CAR extracellular domain is sufficient to permitvirus attachment and entry and that the presence of a GPI anchordoes not preventinfection.

^* Corresponding author. Mailing address: Abramson 1202E, Children's Hospital of Philadelphia, 34th St. and Civic Center Blvd.,Philadelphia, PA 19104. Phone: (215) 590-3771. Fax: (215) 590-2025.E-mail: bergelson{at}emailchop.edu.

Journal of Virology, March 1999, p. 2559-2562, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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