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Journal of Virology, March 1999, p. 2552-2558, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Neoplastic Transformation-Associated Stimulation of the In Vitro Resolution of Concatemer Junction Fragments from Minute Virus of Mice DNA

Gaëlle Kuntz-Simon,dagger Tarig Bashir, Jean Rommelaere,* and Kurt WillwandDagger

Deutsches Krebsforschungszentrum, Department of Applied Tumor Virology, Abt. F0100 and Formation INSERM U375, Heidelberg, Germany

Received 2 October 1998/Accepted 7 December 1998

Minute virus of mice (MVM) shows an oncotropic behavior reflected by its ability to amplify its genome more efficiently in a number of transformed versus normal cells. In vivo and in vitro studies revealed that the major effect of cell transformation on MVM DNA replication occurs at the level of double-stranded replicative-form amplification. In particular, resolution of MVM DNA concatemers into monomers was found to be highly sensitive to neoplastic transformation.

* Corresponding author. Mailing address: Deutsches Krebsforschungszentrum, Applied Tumor Virology, Abt. F0100 and Formation INSERM U375, Postfach 101949, D-69009 Heidelberg, Germany. Phone: (49) 6221 42 49 60. Fax: (49) 6221 42 49 62. E-mail: j.rommelaere{at}dkfz-heidelberg.de.

dagger Present address: CNEVA-Ploufragan, Unité de Virologie Immunologie Parasitologie Aviaires et Cunicoles, BP 53, F-22440 Ploufragan, France.

Dagger Present address: Department of Internal Medicine, University of Heidelberg, D-69115 Heidelberg, Germany.

Journal of Virology, March 1999, p. 2552-2558, Vol. 73, No. 3
0022-538X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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